Born to Malayali and Telugu parents, Samantha was brought up in Chennai and pursued a career in modeling during her late teens. Despite signing up to Ravi Varman's Moscowin Kavery in 2007, her first release happened to be the critically acclaimed 2010 Telugu romance film, Ye Maaya Chesave, directed by Gautham Menon. She has then later appeared in critically acclaimed and commercially successful Telugu movies like Brindavanam, Dookudu and Eega establishing herself as a leading contemporary actress in Telugu Cinema.
Samantha is currently working on more than half-a-dozen projects. She is filming for the big budget films Seethamma Vakitlo Sirimalle Chettu that features Venkatesh and Mahesh Babu in the lead, Autonagar Surya opposite Naga Chaitanya under the direction of Deva Katta and Nandini Reddy's Jabardasth co-starring Siddharth